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Human Tumors (in vivo) | Rodent and Human Xenografts | Non-Tumor Pathologic Conditions | Cells or Spheroids | Non-Invasive Imaging (PET, MR, EPR, US) | Molecular | Review Papers

Human Tumors (in vivo):

  1. Evans SM. Fraker D. Hahn SM. Gleason K. Jenkins WT. Jenkins K. Hwang WT. Zhang P. Mick R. Koch CJ.
    EF5 binding and clinical outcome in human soft tissue sarcomas.
    International Journal of Radiation Oncology, Biology, Physics. 64(3):922-7, 2006 Mar
    View Abstract

  2. Busch TM. Hahn SM. Wileyto EP. Koch CJ. Fraker DL. Zhang P. Putt M. Gleason K. Shin DB. Emanuele MJ. Jenkins K. Glatstein E. Evans SM.
    Hypoxia and Photofrin uptake in the intraperitoneal carcinomatosis and sarcomatosis of photodynamic therapy patients.
    Clinical Cancer Research. 10(14):4630-8, 2004 Jul 15.
    View Abstract

  3. Evans SM. Judy KD. Dunphy I. Jenkins WT. Hwang WT. Nelson PT. Lustig RA. Jenkins K. Magarelli DP. Hahn SM. Collins RA. Grady MS. Koch CJ.
    Hypoxia is important in the biology and aggression of human glial brain tumors. [see comment].
    Clinical Cancer Research. 10(24):8177-84, 2004 Dec 15.
    View Abstract

  4. Evans SM. Judy KD. Dunphy I. Jenkins WT. Nelson PT. Collins R. Wileyto EP. Jenkins K. Hahn SM. Stevens CW. Judkins AR. Phillips P. Geoerger B. Koch CJ.
    Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding.
    Cancer Research. 64(5):1886-92, 2004 Mar 1.
    View Abstract

  5. Evans SM. Hahn SM. Magarelli DP. Zhang PJ. Jenkins WT. Fraker DL. Hsi RA. McKenna WG. Koch CJ.
    Hypoxia in human intraperitoneal and extremity sarcomas.
    International Journal of Radiation Oncology, Biology, Physics. 49(2):587-96, 2001 Feb 1.
    View Abstract

  6. Koch CJ. Hahn SM. Rockwell K Jr. Covey JM. McKenna WG. Evans SM.
    Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles.
    Cancer Chemotherapy & Pharmacology. 48(3):177-87, 2001 Sep.
    View Abstract

  7. Evans SM. Hahn S. Pook DR. Jenkins WT. Chalian AA. Zhang P. Stevens C. Weber R. Weinstein G. Benjamin I. Mirza N. Morgan M. Rubin S. McKenna WG. Lord EM. Koch CJ.
    Detection of hypoxia in human squamous cell carcinoma by EF5 binding. [Clinical Trial. Clinical Trial, Phase I. Clinical Trial, Phase II. Multicenter Study]
    Cancer Research. 60(7):2018-24, 2000 Apr 1.
    View Abstract

Rodent and Human Xenografts:

  1. Fenton BM. Paoni SF. Beauchamp BK. Ding I.
    Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis.
    British Journal of Cancer. 86(11):1831-6, 2002 Jun 5.

  2. Koch CJ. Oprysko PR. Shuman AL. Jenkins WT. Brandt G. Evans SM.
    Radiosensitization of hypoxic tumor cells by dodecafluoropentane: a gas-phase perfluorochemical emulsion.
    Cancer Research. 62(13):3626-9, 2002 Jul 1.
    View Abstract

  3. Ding I. Sun JZ. Fenton B. Liu WM. Kimsely P. Okunieff P. Min W.
    Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 murine mammary carcinomas.
    Cancer Research. 61(2):526-31, 2001 Jan 15.

  4. Fenton BM. Beauchamp BK. Paoni SF. Okunieff P. Ding I.
    Characterization of the effects of antiangiogenic agents on tumor pathophysiology.
    American Journal of Clinical Oncology. 24(5):453-7, 2001 Oct.

  5. Fenton BM.
    Influence of hydralazine administration on oxygenation in spontaneous and transplanted tumor models.
    International Journal of Radiation Oncology, Biology, Physics. 49(3):799-808, 2001 Mar 1.

  6. Fenton BM. Lord EM. Paoni SF.
    Intravascular HBO(2) saturations, perfusion and hypoxia in spontaneous and transplanted tumor models.
    International Journal of Cancer. 93(5):693-8, 2001 Sep 1.

  7. Fenton BM. Lord EM. Paoni SF.
    Effects of radiation on tumor intravascular oxygenation, vascular configuration, development of hypoxia, and clonogenic survival.
    Radiation Research. 155(2):360-8, 2001 Feb.

  8. Vukovic V. Nicklee T. Hedley DW.
    Differential effects of buthionine sulphoximine in hypoxic and non-hypoxic regions of human cervical carcinoma xenografts.
    Radiotherapy & Oncology. 60(1):69-73, 2001 Jul.

  9. Vukovic V. Haugland HK. Nicklee T. Morrison AJ. Hedley DW.
    Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts.
    Cancer Research. 61(20):7394-8, 2001 Oct 15.

  10. Busch TM. Hahn SM. Evans SM. Koch CJ.
    Depletion of tumor oxygenation during photodynamic therapy: detection by the hypoxia marker EF3 [2-(2-nitroimidazol-1[H]-yl)-N-(3,3,3-trifluoropropyl)acetamide ].
    Cancer Research. 60(10):2636-42, 2000 May 15.
    View Abstract

  11. Fenton BM. Lord EM. Paoni SF.
    Enhancement of tumor perfusion and oxygenation by carbogen and nicotinamide during single- and multifraction irradiation.
    Radiation Research. 153(1):75-83, 2000 Jan.

  12. Jenkins WT. Evans SM. Koch CJ.
    Hypoxia and necrosis in rat 9L glioma and Morris 7777 hepatoma tumors: comparative measurements using EF5 binding and the Eppendorf needle electrode.
    International Journal of Radiation Oncology, Biology, Physics. 46(4):1005-17, 2000 Mar 1.
    View Abstract

  13. Fenton BM. Paoni SF. Lee J. Koch CJ. Lord EM.
    Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements.
    British Journal of Cancer. 79(3-4):464-71, 1999 Feb.
    View Abstract

  14. Gee MS. Koch CJ. Evans SM. Jenkins WT. Pletcher CH Jr. Moore JS. Koblish HK. Lee J. Lord EM. Trinchieri G. Lee WM.
    Hypoxia-mediated apoptosis from angiogenesis inhibition underlies tumor control by recombinant interleukin 12.
    Cancer Research. 59(19):4882-9, 1999 Oct 1.
    View Abstract

  15. Kavanagh MC. Tsang V. Chow S. Koch C. Hedley D. Minkin S. Hill RP.
    A comparison in individual murine tumors of techniques for measuring oxygen levels.
    International Journal of Radiation Oncology, Biology, Physics. 44(5):1137-46, 1999 Jul 15.
    View Abstract

  16. Moreno-Merlo F. Nicklee T. Hedley DW.
    Association between tissue hypoxia and elevated non-protein sulphydryl concentrations in human cervical carcinoma xenografts.
    British Journal of Cancer. 81(6):989-93, 1999 Nov.

  17. Yapp DT. Lloyd DK. Zhu J. Lehnert S.
    Radiosensitization of a mouse tumor model by sustained intra-tumoral release of etanidazole and tirapazamine using a biodegradable polymer implant device.
    Radiotherapy & Oncology. 53(1):77-84, 1999 Oct.

  18. Koch CJ. Chasan JE. Jenkins WT. Chan CY. Laughlin KM. Evans SM.
    Co-localization of hypoxia and apoptosis in irradiated and untreated HCT116 human colon carcinoma xenografts.
    Advances in Experimental Medicine & Biology. 454:611-8, 1998.
    View Abstract

  19. Damert A. Machein M. Breier G. Fujita MQ. Hanahan D. Risau W. Plate KH.
    Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.
    Cancer Research. 57(17):3860-4, 1997 Sep 1.

  20. Evans SM. Koch CJ. Laughlin KM. Jenkins WT. Van Winkle T. Wilson DF.
    Tamoxifen induces hypoxia in MCF-7 xenografts.
    Cancer Research. 57(22):5155-61, 1997 Nov 15.
    View Abstract

  21. Siim BG. Menke DR. Dorie MJ. Brown JM.
    Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia. \
    Cancer Research. 57(14):2922-8, 1997 Jul 15.

  22. Evans SM. Jenkins WT. Joiner B. Lord EM. Koch CJ.
    2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors.
    Cancer Research. 56(2):405-11, 1996 Jan 15.
    View Abstract

  23. Laughlin KM. Evans SM. Jenkins WT. Tracy M. Chan CY. Lord EM. Koch CJ.
    Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors.
    Journal of Pharmacology & Experimental Therapeutics. 277(2):1049-57, 1996 May.
    View Abstract

  24. Lee J. Siemann DW. Koch CJ. Lord EM.
    Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts.
    International Journal of Cancer. 67(3):372-8, 1996 Jul 29.
    View Abstract

  25. Evans SM. Joiner B. Jenkins WT. Laughlin KM. Lord EM. Koch CJ.
    Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide].
    British Journal of Cancer. 72(4):875-82, 1995 Oct.
    View Abstract

  26. Lord EM. Harwell L. Koch CJ.
    Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.
    Cancer Research. 53(23):5721-6, 1993 Dec 1.
    View Abstract

  27. Hasan T.
    Combining vascular and cellular targeting regimens enhances the efficacy of photodynamic therapy.
    International Journal of Radiation Oncology, Biology, Physics. 61(4):1216-26, 2005 Mar 15.

  28. Fenton BM. Paoni SF. Grimwood B. Ding I.
    Varied response of spontaneous tumors to antiangiogenic agents.
    Advances in Experimental Medicine & Biology. 566:59-65, 2005.

  29. Nelson DW. Cao H. Zhu Y. Sunar-Reeder B. Choi CY. Faix JD. Brown JM. Koong AC. Giaccia AJ. Le QT.
    A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia.
    Cancer Research. 65(14):6151-8, 2005 Jul 15.

  30. Primeau AJ. Rendon A. Hedley D. Lilge L. Tannock IF.
    The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors.
    Clinical Cancer Research. 11(24 Pt 1):8782-8, 2005 Dec 15.

  31. Schroeder T. Yuan H. Viglianti BL. Peltz C. Asopa S. Vujaskovic Z. Dewhirst MW.
    Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.
    Cancer Research. 65(12):5163-71, 2005 Jun 15.

  32. Cairns RA. Hill RP.
    Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma.
    Cancer Research. 64(6):2054-61, 2004 Mar 15.

  33. Pinel S. Barberi-Heyob M. Cohen-Jonathan E. Merlin JL. Delmas C. Plenat F. Chastagner P.
    Erythropoietin-induced reduction of hypoxia before and during fractionated irradiation contributes to improvement of radioresponse in human glioma xenografts.
    International Journal of Radiation Oncology, Biology, Physics. 59(1):250-9, 2004 May 1.

  34. Skov K. Adomat H. Bowden M. Dragowska W. Gleave M. Koch CJ. Woo J. Yapp DT.
    Hypoxia in the androgen-dependent Shionogi model for prostate cancer at three stages.
    Radiation Research. 162(5):547-53, 2004 Nov.
    View Abstract

  35. Schouwink H. Oppelaar H. Ruevekamp M. van der Valk M. Hart G. Rijken P. Baas P. Stewart FA.
    Oxygen depletion during and after mTHPC-mediated photodynamic therapy in RIF1 and H-MESO1 tumors.
    Radiation Research. 159(2):190-8, 2003 Feb.

  36. Vordermark D. Brown JM.
    Evaluation of hypoxia-inducible factor-1alpha (HIF-1alpha) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies.[see comment].
    International Journal of Radiation Oncology, Biology, Physics. 56(4):1184-93, 2003 Jul 15.

  37. Busch TM. Wileyto EP. Emanuele MJ. Del Piero F. Marconato L. Glatstein E. Koch CJ.
    Photodynamic therapy creates fluence rate-dependent gradients in the intratumoral spatial distribution of oxygen.
    Cancer Research. 62(24):7273-9, 2002 Dec 15.
    View Abstract

Non-Tumor Pathologic Conditions:

  1. Matthews J. Adomat H. Farrell N. King P. Koch C. Lord E. Palcic B. Poulin N. Sangulin J. Skov K.
    Immunocytochemical labelling of aerobic and hypoxic mammalian cells using a platinated derivative of EF5.
    British Journal of Cancer - Supplement. 27:S200-3, 1996 Jul.
    View Abstract

  2. Wikenheiser J. Doughman YQ. Fisher JA. Watanabe M.
    Differential levels of tissue hypoxia in the developing chicken heart.
    Developmental Dynamics. 235(1):115-23, 2006 Jan.
    View Abstract

  3. Tsai MC. Chakravarty S. Zhu G. Xu J. Tanaka K. Koch C. Tufariello J. Flynn J. Chan J.
    Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension.
    Cellular Microbiology. 8(2):218-32, 2006 Feb.
    View Abstract

  4. Wang B. Ansari R. Sun Y. Postlethwaite AE. Weber KT. Kiani MF.
    The scar neovasculature after myocardial infarction in rats.
    American Journal of Physiology - Heart & Circulatory Physiology. 289(1):H108-13, 2005 Jul.

  5. West H. Richardson WD. Fruttiger M.
    Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes.
    Development. 132(8):1855-62, 2005 Apr.

  6. Ivnitski-Steele ID. Sanchez A. Walker MK.
    2,3,7,8-tetrachlorodibenzo-p-dioxin reduces myocardial hypoxia and vascular endothelial growth factor expression during chick embryo development.
    Birth Defects Research. 70(2):51-8, 2004 Feb.

  7. Sugishita Y. Watanabe M. Fisher SA.
    Role of myocardial hypoxia in the remodeling of the embryonic avian cardiac outflow tract.
    Developmental Biology. 267(2):294-308, 2004 Mar 15.

  8. Chavez JC. LaManna JC.
    Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1.
    Journal of Neuroscience. 22(20):8922-31, 2002 Oct 15.

  9. Li YQ. Ballinger JR. Nordal RA. Su ZF. Wong CS.
    Hypoxia in radiation-induced blood-spinal cord barrier breakdown.
    Cancer Research. 61(8):3348-54, 2001 Apr 15.

  10. Seidner SR. Chen YQ. Oprysko PR. Mauray F. Tse MM. Lin E. Koch C. Clyman RI.
    Combined prostaglandin and nitric oxide inhibition produces anatomic remodeling and closure of the ductus arteriosus in the premature newborn baboon.
    Pediatric Research. 50(3):365-73, 2001 Sep.
    View Abstract

  11. Kajino H. Chen YQ. Chemtob S. Waleh N. Koch CJ. Clyman RI.
    Tissue hypoxia inhibits prostaglandin and nitric oxide production and prevents ductus arteriosus reopening.
    American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 279(1):R278-86, 2000 Jul.
    View Abstract

  12. Marti HJ. Bernaudin M. Bellail A. Schoch H. Euler M. Petit E. Risau W.
    Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia.
    American Journal of Pathology. 156(3):965-76, 2000 Mar.

  13. Maury P. Zimmermann M. Metzger J. Reynard C. Dorsaz P. Adamec R.
    Amiodarone therapy for sustained ventricular tachycardia after myocardial infarction: long-term follow-up, risk assessment and predictive value of programmed ventricular stimulation.
    International Journal of Cardiology. 76(2-3):199-210, 2000 Nov-Dec. .

  14. Bergeron M. Evans SM. Sharp FR. Koch CJ. Lord EM. Ferriero DM.
    Detection of hypoxic cells with the 2-nitroimidazole, EF5, correlates with early redox changes in rat brain after perinatal hypoxia-ischemia.
    Neuroscience. 89(4):1357-66, 1999.
    View Abstract

  15. Khan S. Cleveland RP. Koch CJ. Schelling JR.
    Hypoxia induces renal tubular epithelial cell apoptosis in chronic renal disease.
    Laboratory Investigation. 79(9):1089-99, 1999 Sep.
    View Abstract

  16. Meeson AP. Argilla M. Ko K. Witte L. Lang RA.
    VEGF deprivation-induced apoptosis is a component of programmed capillary regression.
    Development. 126(7):1407-15, 1999 Apr.

  17. Hicks KO. Fleming Y. Siim BG. Koch CJ. Wilson WR.
    Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model.
    International Journal of Radiation Oncology, Biology, Physics. 42(3):641-9, 1998 Oct 1.
    View Abstract

  18. Shapiro IM. Mansfield KD. Evans SM. Lord EM. Koch CJ.
    Chondrocytes in the endochondral growth cartilage are not hypoxic.
    American Journal of Physiology. 272(4 Pt 1):C1134-43, 1997 Apr.

Cells or Spheroids:

  1. Woods ML. Koch CJ. Lord EM.
    Detection of individual hypoxic cells in multicellular spheroids by flow cytometry using the 2-nitroimidazole, EF5, and monoclonal antibodies.
    International Journal of Radiation Oncology, Biology, Physics. 34(1):93-101, 1996 Jan 1.
    View Abstract

  2. Waleh NS. Brody MD. Knapp MA. Mendonca HL. Lord EM. Koch CJ. Laderoute KR. Sutherland RM.
    Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker.
    Cancer Research. 55(24):6222-6, 1995 Dec 15.

Non-Invasive Imaging (PET, MR, EPR, US):

  1. Cheguillaume A. Gillart J. Labar D. Gregoire V. Marchand-Brynaert J.
    Perfluorinated markers for hypoxia detection: synthesis of sulfur-containing precursors and [18F]-labelling.
    Bioorganic & Medicinal Chemistry. 13(4):1357-67, 2005 Feb 15.

  2. Ziemer LS. Lee WM. Vinogradov SA. Sehgal C. Wilson DF.
    Oxygen distribution in murine tumors: characterization using oxygen-dependent quenching of phosphorescence.
    Journal of Applied Physiology. 98(4):1503-10, 2005 Apr.

  3. Mahy P. De Bast M. Leveque PH. Gillart J. Labar D. Marchand J. Gregoire V.
    Preclinical validation of the hypoxia tracer 2-(2-nitroimidazol-1-yl)- N-(3,3,3-[(18)F]trifluoropropyl)acetamide, [(18)F]EF3.
    European Journal of Nuclear Medicine & Molecular Imaging. 31(9):1263-72, 2004 Sep.

  4. Salmon HW. Siemann DW.
    Utility of 19F MRS detection of the hypoxic cell marker EF5 to assess cellular hypoxia in solid tumors.
    Radiotherapy & Oncology. 73(3):359-66, 2004 Dec.

  5. Koch CJ. Evans SM.
    Non-invasive PET and SPECT imaging of tissue hypoxia using isotopically labeled 2-nitroimidazoles.
    Advances in Experimental Medicine & Biology. 510:285-92, 2003.
    View Abstract

  6. Mahy P. De Bast M. Gallez B. Gueulette J. Koch CJ. Scalliet P. Gregoire V.
    In vivo colocalization of 2-nitroimidazole EF5 fluorescence intensity and electron paramagnetic resonance oximetry in mouse tumors.
    Radiotherapy & Oncology. 67(1):53-61, 2003 Apr.
    View Abstract

  7. Ziemer LS. Evans SM. Kachur AV. Shuman AL. Cardi CA. Jenkins WT. Karp JS. Alavi A. Dolbier WR Jr. Koch CJ.
    Noninvasive imaging of tumor hypoxia in rats using the 2-nitroimidazole 18F-EF5.
    European Journal of Nuclear Medicine & Molecular Imaging. 30(2):259-66, 2003 Feb.
    View Abstract

  8. Dolbier WR Jr. Li AR. Koch CJ. Shiue CY. Kachur AV.
    [18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure.
    Applied Radiation & Isotopes. 54(1):73-80, 2001 Jan.
    View Abstract

  9. Josse O. Labar D. Georges B. Gregoire V. Marchand-Brynaert J.
    Synthesis of [18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia.
    Bioorganic & Medicinal Chemistry. 9(3):665-75, 2001 Mar.

  10. Evans SM. Kachur AV. Shiue CY. Hustinx R. Jenkins WT. Shive GG. Karp JS. Alavi A. Lord EM. Dolbier WR Jr. Koch CJ.
    Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1.
    Journal of Nuclear Medicine. 41(2):327-36, 2000 Feb.
    View Abstract

  11. Evans SM. Laughlin KM. Pugh CR. Sehgal CM. Saunders HM.
    Use of power Doppler ultrasound-guided biopsies to locate regions of tumour hypoxia.
    British Journal of Cancer. 76(10):1308-14, 1997.


  1. Brunner TB. Hahn SM. McKenna WG. Bernhard EJ.
    Radiation sensitization by inhibition of activated Ras.
    Strahlentherapie und Onkologie. 180(11):731-40, 2004 Nov.

  2. Dragowska WH. Warburton C. Yapp DT. Minchinton AI. Hu Y. Waterhouse DN. Gelmon K. Skov K. Woo J. Masin D. Huxham LA. Kyle AH. Bally MB.
    HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization.
    Molecular Cancer Research: MCR. 2(11):606-19, 2004 Nov.

  3. Fenton BM. Paoni SF.
    Ding I. Effect of VEGF receptor-2 antibody on vascular function and oxygenation in spontaneous and transplanted tumors.
    Radiotherapy & Oncology. 72(2):221-30, 2004 Aug.

  4. Subramanian L. Crabb JW. Cox J. Durussel I. Walker TM. van Ginkel PR. Bhattacharya S. Dellaria JM. Palczewski K.
    Polans AS. Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma.
    Biochemistry. 43(35):11175-86, 2004 Sep 7.

  5. Brunner TB. Gupta AK. Shi Y. Hahn SM. Muschel RJ. McKenna WG. Bernhard EJ.
    Farnesyltransferase inhibitors as radiation sensitizers.
    International Journal of Radiation Biology. 79(7):569-76, 2003 Jul.

  6. Maity A. Sall W. Koch CJ. Oprysko PR. Evans SM.
    Low pO2 and beta-estradiol induce VEGF in MCF-7 and MCF-7-5C cells: relationship to in vivo hypoxia.
    Breast Cancer Research & Treatment. 67(1):51-60, 2001 May.
    View Abstract

  7. Ziemer LS. Koch CJ. Maity A. Magarelli DP. Horan AM. Evans SM.
    Hypoxia and VEGF mRNA expression in human tumors.
    Validation Studies] Neoplasia (New York). 3(6):500-8, 2001 Nov-Dec.
    View Abstract

  8. Ryan HE. Lo J. Johnson RS.
    HIF-1 alpha is required for solid tumor formation and embryonic vascularization.
    EMBO Journal. 17(11):3005-15, 1998 Jun 1.

Review Papers:

  1. Koch CJ.
    Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5.
    Methods in Enzymology. 352:3-31, 2002.
    View Abstract

  2. Evans SM. Jenkins WT. Shapiro M. Koch CJ.
    Evaluation of the concept of "hypoxic fraction" as a descriptor of tumor oxygenation status.
    Advances in Experimental Medicine & Biology. 411:215-25, 1997.
    View Abstract

  3. Evans SM. Hahn SM. Magarelli DP. Koch CJ.
    Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation.
    American Journal of Clinical Oncology. 24(5):467-72, 2001 Oct.
    View Abstract

  4. Evans, S. M. and Koch, C. J.
    Prognostic significance of tumor oxygenation in humans.
    Cancer Letters, 195: 1-16, 2003.
    View Abstract

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